Detecting cell-adhesive sites in extracellular matrix using force spectroscopy mapping
نویسندگان
چکیده
منابع مشابه
Detecting coevolving amino acid sites using Bayesian mutational mapping
MOTIVATION The evolution of protein sequences is constrained by complex interactions between amino acid residues. Because harmful substitutions may be compensated for by other substitutions at neighboring sites, residues can coevolve. We describe a Bayesian phylogenetic approach to the detection of coevolving residues in protein families. This method, Bayesian mutational mapping (BMM), assigns ...
متن کاملSingle-cell force spectroscopy.
The controlled adhesion of cells to each other and to the extracellular matrix is crucial for tissue development and maintenance. Numerous assays have been developed to quantify cell adhesion. Among these, the use of atomic force microscopy (AFM) for single-cell force spectroscopy (SCFS) has recently been established. This assay permits the adhesion of living cells to be studied in near-physiol...
متن کاملCell behavior on extracellular matrix mimic materials based on mussel adhesive protein fused with functional peptides.
Adhesion of cells to surfaces is a basic and important requirement in cell culture and tissue engineering. Here, we designed artificial extracellular matrix (ECM) mimics for efficient cellular attachment, based on mussel adhesive protein (MAP) fusion with biofunctional peptides originating from ECM materials, including fibronectin, laminin, and collagen. Cellular behaviors, including attachment...
متن کاملDetecting regulatory sites using PhyloGibbs.
PhyloGibbs is a program that uses Gibbs sampling to predict putative binding sites for transcription factors in DNA. It has two notable advances over previous algorithms for this task: it handles phylogenetically related sequence systematically, and it evaluates the significance of each predicted site via statistical sampling. In this article, we explain how to use PhyloGibbs effectively. We de...
متن کاملCell Migration through Extracellular Matrix
Every so often, a paper comes along that brings clarity to an issue. Clarity is not necessarily a final resolution, but rather a conceptual framework for productively addressing that issue. Such a paper could be based on a breakthrough discovery, an intriguing observation, a flash of intuition , or a systematic analysis. An excellent example of the latter is in this issue of The Journal of Cell...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Physics: Condensed Matter
سال: 2010
ISSN: 0953-8984,1361-648X
DOI: 10.1088/0953-8984/22/19/194102